RESEARCH PAPERS

  Citations (Google Scholar): ~9,000

H-index: 50

https://scholar.google.com/citations?user=14YcD9oAAAAJ&hl=en&oi=ao

  1. Han SY*, Iliopoulos D*, Druck T, Guler G, Grubbs CJ, Pereira M, Zhang Z, You M, Lubet RA, Fong LY, Huebner K. CpG methylation in the Fhit regulatory region: relation to Fhit expression in murine tumors. Oncogene 23:3990-8, 2004. *equal contribution 
  1. Iliopoulos D, Guler G, Han SY, Johnston D, Druck T, McCorkell KA, Palazzo J, McCue P, Baffa R, Huebner K. Fragile genes as potential biomarkers: Epigenetic control of FHIT and WWOX in lung, breast and bladder cancer. Oncogene 24: 1625-33, 2005. 
  1. Fabbri M*, Iliopoulos D*, Trapasso F, Aqeilan RI, Cimmino A, Zanesi N, Yendamuri S, Han SY, Amadori D, Huebner K and Croce CM. WWOX gene therapy prevents lung cancer growth in vitro and in vivo. Proc Natl Acad Sci USA 102: 15611-6, 2005. *equal contribution 
  1. Guler G*, Iliopoulos D*#, Han SY, Fong LY, Lubet RA, Grubbs CJ and Huebner K. Hypermethylation patterns in the Fhit regulatory region are tissue specific. Mol Carcinog, 43:175-81, 2005. *equal contribution, #corresponding author 
  1. Iliopoulos D, Sekerli E, Vassiliou G, Sidiropoulou V, Topalidis A, Dimopoulou D, Voyiatzis N. Patau Syndrome with a long survival (146 months): a clinical report and review of literature. Am J Med Genet 140:92-3, 2006. 
  1. Qin HR, Iliopoulos D, Semba S, Fabbri M, Druck T, Volinia S, Croce CM, Morrison CD, Klein RD, and Huebner K. Role of WWOX tumor suppressor gene in prostate cancer Cancer Res. 66: 6477-81, 2006. 
  1. Semba S, Trapasso F, Fabbri M, McCorkell KA, Volinia S, Druck T, Iliopoulos D, Ishii H, Barnes LD, Croce CM and Huebner K. Fhit modulation of the Akt-Survivin pathway in lung cancer cells: Fhit-tyrosine 111 (Y114) is essential. Oncogene 5: 2860-72, 2006. 
  1. Semba S, Han SY, Qin HR, McCorkell KA, Iliopoulos D, Pekarsky Y, Druck T, Trapasso F, Croce CM and Huebner K. Biological functions of mammalian Nit1, the counterpart of NitFhit Rosetta Stone protein: a possible tumor suppressor. J Biol Chem 281: 28244-53, 2006.
  1. Petrocca F*, Iliopoulos D*, Qin HR, Nicoloso MS, Yendamuri S, Wojcik SE, Shimizu M, Di Leva G, Vecchione A, Trapasso F, Godwin AK, Negrini M, Calin GA, Croce CM. Alterations of the tumor suppressor gene ARLTS1 in ovarian cancer. Cancer Res. 66:10287-91, 2006. *equal contribution
  1. Iliopoulos D, Guler G, Han SY, Druck T, McCorkell KA and Huebner K. Role of FHIT and WWOX fragile genes in cancer. Cancer Lett 232: 27-36, 2006
  1. Pichiorri F, Trapasso F, Palombo T, Aqeilan RI, Drusco A, Blaser BW, Iliopoulos D, Caligiuri MA, Huebner K, Croce CM. Preclinical assessment of FHIT gene replacement therapy in human leukemia using a chimeric adenovirus, Ad5/F35. Clin Cancer Res 12: 3494-501, 2006.
  1. Cantor JP*, Iliopoulos D*, Rao AS, Druck T, Semba S, Han SY, McCorkell KA, Lakshman TV, Collins JE, Wachsberger P, Friedberg JS, Huebner K. Epigenetic modulation of tumor suppressor expression in lung cancer xenografts suppresses tumorigenicity. Int J Cancer 120: 24-31, 2006. *equal contribution
  1. Iliopoulos D, Fabbri M, Druck T, Qin HR, Han SY, Huebner K. Inhibition of breast cancer cell growth in vitro and in vivo: effect of restoration of Wwox expression. Clin Cancer Res 13: 268-74, 2007.
  1. Qin HR, Iliopoulos D, Nakamura T, Costinean S, Volinia S, Druck T, Sun J, Okumura H, Huebner K. Wwox suppresses prostate cancer cell growth through modulation of ErbB2-induced androgen receptor signalling. Mol Cancer Res, 5: 957-65, 2007.
  1. Guler G, Iliopoulos D, Guler N, Himmetoglu C, Hayran M, Huebner K. Wwox and Ap2gamma expression levels predict tamoxifen response. Clin Cancer Res 13: 6115-21, 2007. 
  1. Petrocca F, Visone R, Onelli MR, Shah MH, Nicoloso MS, de Martino I, Iliopoulos D, Pilozzi E, Liu CG, Negrini M, Cavazzini L, Volinia S, Alder H, Ruco L, Baltassarre G, Croce CM, Vecchione A. E2F1-regulated MicroRNAs impair TGFβ-dependent cell cycle arrest and apoptosis in gastric cancer. Cancer Cell 13: 272-286, 2008. 
  1. Drakaki A & Iliopoulos D*. MicroRNA gene networks in oncogenesis. Genomics 10:35-41, 2009. *corresponding author 
  1. Iliopoulos D, Bimpaki EI, Nesterova M, Stratakis CA. MicroRNA Signature of Primary Pigmented Nodular Adrenocortical Disease: Clinical Correlations and Regulation of Wnt Signaling. Cancer Res 69:3278-82, 2009.

Evaluated as an “must read” paper by Faculty of 1000 Medicine.

  1. Hirsch HA*, Iliopoulos D*, Tsichlis PN, Struhl K. Metformin selectively targets cancer stem cells and acts together with chemotherapy to block tumor growth and prolong remission. Cancer Res, 69:7507-11, 2009. *equal contribution

Evaluated as a “must read” paper by Faculty of 1000 Biology Cover of October 1st

Cancer Research Issue. This work made an impact all over the world as more than 30 prominent media publications announced these findings. Examples of media reports that featured this work include: In United States (Forbes, US News & World Report, Reuters and Wall Street Journal), in France (AFP), in UK (BBC News, Cancer Research UK), in Germany (Wissenschaft), in Portugal (Publico), in Canada (CTV), in Australia (Sidney Morning Herald), in Qatar (Gulf Times) and in India (Press Trust of India). 

  1. Iliopoulos D, Polytarchou C, Hatziapostolou M, Kottakis F, Maroulakou IG, Struhl K, Tsichlis PN. MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells. Science Signaling, 2 (92): ra62, 2009.

Evaluated as a “must read” paper by Faculty of 1000 Biology 

  1. Androulidaki A*, Iliopoulos D*, Arranz A, Doxaki C, Schworer S, Zacharioudaki V, Margioris AN, Tsichlis PN, Tsatsanis C. The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs. Immunity 31:220-31, 2009. *equal contribution

This was one of the first studies showing that microRNAs regulating the expression of essential inflammatory molecules. Specifically, we found that let-7e microRNA regulates the expression of Toll-like Receptor 4 (TLR4) and miR-155 regulates the expression of SOCS1.

  1. Iliopoulos D, Hirsch HA, Struhl K. An epigenetic switch involving NF-κB, Lin28, let-7 microRNA, and IL6 links inflammation to cell transformation. Cell, 139:693-706, 2009.

Preview article by Drost J & Agami R in the same issue. This article was presented in Research Highlights of Nature Reviews Immunology (9: 822, 2009) and Science (326, 2009). This article was presented in the Focus Magazine (April 23, 2010) and websites of Harvard Medical School, Dental School and School of Public Health. Evaluated as an “exceptional” paper by Faculty of 1000 Biology and as a “recommended” paper by Faculty of 1000 Medicine. 

  1. Hirsch HA*, Iliopoulos D*, Joshi A*, Zhang Y, Jaeger SA, Bulyk M, Liu SX, Struhl K. A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases. Cancer Cell 17: 348-61, 2010. *equal contribution

The findings of this study were featured in “The Scientist” magazine (article by Megan Scudellari on April 12th, 2010). This article was presented in the Focus Magazine (April 23, 2010) and websites of Harvard Medical School, Dental School and School of Public Health. Evaluated as an “exceptional” paper by Faculty of 1000 Biology. This article was presented in Nature Reviews Genetics (11:386, 2010) and Nature Reviews Cancer (10:387, 2010).

  1. Iliopoulos D, Lindahl-Allen M, Polytarchou C, Hirsch HA, Tsichlis PN, Struhl K. Loss of miR-200 inhibition of Suz12 leads to Polycomb-mediated repression required for the formation and maintenance of cancer stem cells. Mol Cell, 39:761-72, 2010. Preview in the same issue by Zahnow CA & Baylin SB 
  1. Iliopoulos D, Jaeger SA, Hirsch HA, Bulyk ML, Struhl K. Stat3 activation of miR-21 and miR-181b, via PTEN and CYLD, are part of the epigenetic switch linking inflammation to cancer. Mol Cell, 39:493-506, 2010.

This article was presented in Research Highlights of Nature Reviews Cancer (10:664-5, 2010). 

  1. Levy C, Khaled M, Iliopoulos D, Janas M, Schubert S, Pinner S, Chen PH, Li S, Fletcher A, Yokoyama S, Scott KL, Garraway LA, Song JS, Granter SR, Turley SJ, Fisher DE, Novina CD. Intronic miR-211 assumes the tumor suppressive function of its host gene in melanoma. Mol Cell, 40:841-9, 2010.

Evaluated as an “exceptional” paper by Faculty of 1000 Biology

  1. Iliopoulos D, Drosatos K, Hiyama Y, Goldberg IJ, Zannis VI. MicroRNA-370 controls the expression of microRNA-122 and Cpt1alpha and affects lipid metabolism. J Lipid Res, 51:1513-23, 2010.

Cover of June 1st Journal of Lipid Research Issue.

  1. Bimpaki EI, Iliopoulos D, Moraitis A, Stratakis CA. MicroRNA signature in massive macronodular adrenocortical disease and implications for adrenocortical tumourigenesis. Clin Endocrinol (Oxf) 72:744-51, 2010.
  1. Meissner TB, Li A, Biswas A, Lee KH, Liu YJ, Bayir E, Iliopoulos D, van den Elsen P, Kobayashi KS. NLRC5 is a transcriptional regulator of MHC class I genes. Proc Natl Acad Sci USA, 107:13794-9,
  1. Stagakis E, Bertsias G, Verginis P, Nakou M, Hatziapostolou M, Kritikos H, Iliopoulos D, Boumpas DT. Identification of novel microRNA signatures linked to human lupus disease activity and pathogenesis: miR-21 regulates aberrant T cell responses through regulation of PDCD4 expression. Ann Rheum Dis 70:1496-506, 2011.

This was the first study showing that microRNAs are involved in the pathogenesis of systemic lupus erythematosus.

  1. Iliopoulos D, Kavousanaki M, Ioannou M, Boumpas D, Verginis P. The negative costimulatory molecular PD-1 modulates the balance between immunity and tolerance via miR-21. Eur J Immunol 41:1754-63, 2011.
  1. Iliopoulos D, Hirsch HA, Struhl K. Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types. Cancer Res. 71:3196-201, 2011.
  1. Iliopoulos D, Hirsch HA, Wang G, Struhl K. Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion. Proc Natl Acad Sci USA, 108: 1397-402, 2011.

This was the first study showing that inflammatory stimuli affect oncogenesis through regulation of the equilibrium between stem and non-stem cancer cells.

  1. Polytarchou C, Iliopoulos D, Hatziapostolou M, Kottakis F, Maroulakou I, Struhl K, Tsichlis PN. Akt2 regulates all Akt isoforms and promotes resistance to hypoxia through induction of miR-21 upon oxygen deprivation. Cancer Res. 71:4720-31, 2011.
  1. Hatziapostolou M & Iliopoulos D*. Epigenetic aberrations during oncogenesis. Cell Mol Life Sci. 68:1681-702, 2011. *corresponding author
  1. Iliopoulos D, Rotem A, Struhl K. Inhibition of miR-193a expression by Max and RXRα activates K-Ras and PLAU to mediate distinct aspects of cellular transformation. Cancer Res. 71:5144-53, 2011. 
  1. Bakirtzi K, Hatziapostolou M, Karagiannides I, Polytarchou C, Jaeger S, Iliopoulos D*, Pothoulakis C*. Neurotensin Signaling Activates MicroRNAs-21 and -155 and Akt, Promotes Tumor Growth in Mice and is Increased in Human Colon Tumors. Gastroenterology, 141:1749-61, 2011 *co-last authors

This was the first study showing that neuropeptides regulate the expression of non-coding RNAs in colonic epithelial cells. 

  1. Piskounova E, Polytarchou C, Hagan JP, Thornton JE, Triboulet R, Giacomelli C, Pothoulakis C, Iliopoulos D* & Gregory RI*. Oncogenic Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms. Cell,147:1066-79, 2011 *corresponding authors

This was the first study that showed that LIN28A and LIN28B although they have a very similar sequence their functions and mechanism of regulation are different. 

  1. Hatziapostolou M, Polytarchou C, Aggelidou E, Drakaki A, Poultsides GA, Jaeger SA, Ogata H, Karin M, Struhl K, Hadzopoulou-Cladaras M & Iliopoulos D*. An HNF4α-miRNA Inflammatory Feedback Circuit regulates Hepatocellular Oncogenesis. Cell, 147:1233-47, 2011 *corresponding author

This work made an impact all over the world as more than 20 prominent media publications announced the findings of this study. Furthermore, there are five preview articles about this manuscript in the high impact scientific journals. Specifically:

  1. Schwabe RF & Wang TC, Cancer Cell, 20:698-9, 2011.
  2. Brody RI & Theise ND, Hepatology, 2012.
  3. Cairo S, Buendia MA, J Hepatol, 2012.
  4. Mu W & Hui L, ABBS, 44:279-280, 2012.
  5. Gouleget A & Colnot S, World J Gastroenterol, 2013.
  1. Moon HS, Liu X, Nagel JM, Chamberland JP, Diakopoulos KN, Brinkoetter MT, Hatziapostolou M, Wu Y, Robson SC, Iliopoulos D, Mantzoros CS. Salutary effects of adiponectin on colon cancer: in vivo and in vitro studies in mice. Gut, 62: 561-70, 2012.
  1. Lee JJ, Drakaki A, Iliopoulos D, Struhl K. MiR-27b targets PPARγ to inhibit growth, tumor progression and the inflammatory response to neuroblastoma cells. Oncogene, 31:3818-25, 2012. 
  1. Papadimitriou E, Vasilaki E, Vorvis C, Iliopoulos D, Moustakas A, Kardassis D, Stournaras C. Differential regulation of the two RhoA specific GEF isoforms Net1/Net1A by TGF-β and miR-24: role in epithelial to mesenchymal transition. Oncogene, 31: 2862-75, 2012.
  1. Polytarchou C, Iliopoulos D, Struhl K. Integrated transcriptional regulatory circuit that reinforces the breast cancer stem cell state. Proc Natl Acad Sci USA, 109:14470-5, 2012.
  1. Janas MM, Wang E, Love T, Harris AS, Stevenson K, Semmelmann K, Shaffer JM, Chen PH, Doench JG, Yerramilli S, Neuberg DS, Iliopoulos D, Housman DE, Burge CB, Novina CD. Reduced expression of ribosomal proteins relieves microRNA-mediated repression. Mol Cell, 46:171-186, 2012.
  1. Palumbo T, Faucz FR, Azevedo M, Xekouki P, Iliopoulos D*, Stratakis CA. Functional screen analysis reveals miR-26b and miR-128 as central regulators of pituitary somatomammotrophic tumor growth through activation of the PTEN-AKT pathway. Oncogene, 2012. *corresponding author
  1. Koutsioumpa M, Polytarchou C, Courty J, Zhang Y, Kieffer N, Mikelis C, Skandalis C, Hellman U, Iliopoulos D, Papadimitriou E. Interplay between alpha v beta 3 integrin and nucleolin regulates human endothelial and glioma cell migration. J Biol Chem, 288:343-54, 2013 
  1. Drakaki A, Hatziapostolou M & Iliopoulos D. Therapeutically targeting microRNAs in liver cancer. Curr Pharm Des, 19: 1180-91, 2013. *corresponding author
  1. Hatziapostolou M, Polytarchou C, Iliopoulos D*. MiRNAs link metabolic reprogramming to oncogenesis. Trends in Endocrinol Metab, 24: 361-73, 2013. *corresponding author
  1. Drakaki A, Iliopoulos D*. MicroRNA-gene signaling pathways in pancreatic cancer. Biomed J, 36: 200-8, 2013. *corresponding author 
  1. Hirsch HA, Iliopoulos D, Struhl K. Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth. Proc Natl Acad Sci USA, 110: 972-7, 2013.
  1. Koukos G, Polytarchou C, Kaplan JL, Morley-Fletcher A, Gras-Miralles B, Kokkotou E, Baril-Dore M, Pothoulakis C, Winter HS, Iliopoulos D. MicroRNA-124 regulates STAT3 expression and is down-regulated in colon tissues of pediatric patients with ulcerative colitis. Gastroenterology, 145: 842-52, 2013.

This is the first study implicating the role of microRNAs in the pathogenesis of pediatric ulcerative colitis. 

  1. He G, Dhar D, Nakagawa H, Font-Burgada J, Ogata H, Jiang Y, Shalapour S, Seki E, Yost SE, Jepsen K, Frazer KA, Harismendy O, Hatziapostolou M, Iliopoulos D, Suetsugu A, Hoffman RM, Tateishi R, Koike K, Karin M. Identification of liver cancer progenitors whose malignant progression depends autocrine IL-6 signaling. Cell, 155: 384-96, 2013. 
  1. Bakirtzi K, West G, Fiocchi C, Law IK, Iliopoulos D, Pothoulakis C. The neurotensin-HIF-1a-VEGFa axis orchestrates hypoxia, colonic inflammation and intestinal angiogenesis. Am J Pathol, 184: 3405-14, 2014. 
  1. Sanidas I, Polytarchou C, Hatziapostolou M, Ezell SA, Kottakis F, Hu L, Guo A, Xie J, Comb MJ, Iliopoulos D, Tsichlis PN. Phosphoproteomics screen reveals akt isoform-specific signaling linking RNA processing to lung cancer. Mol Cell, 53: 577-90, 2014. 
  1. Polytarchou C, Koukos G, Iliopoulos D*. Systems biology in inflammatory bowel diseases: ready for prime time. Curr Opin Gastroenterol, 30: 339-46, 2014. *corresponding author
  1. Chen X, Iliopoulos D, Zhang Q, Tang Q, Greenblatt MB, Hatziapostolou M, Lim E, Tam WL, Ni M, Chen Y, Mai J, Shen H, Hu DZ, Adoro S, Hu B, Song M, Tan C, Landis MD, Ferrari M, Shin SJ, Brown M, Chang JC, Lix XS, Glimcher LH. XBP1 promotes triple-negative breast cancer by controlling the HIF1a pathway. Nature, 508: 103-7, 2014.

This is the first study identifying a biomarker unique for triple negative breast cancer. These findings were published in different media all over the world (Genetic Engineering News, Cornell Chronicle, Bionews Texas, EurekAlert, Oncology Nurse Advisor, Capital New York, Informationsdienst Wissenschaft). Previews for this article were written in the following journals:

  1. Cancer Discovery, April 3, 2014
  2. Breast Cancer Research, 16: 471, 2014.
  3. ASCO Post, March 27, 2014. 
  1. Iliopoulos D. MicroRNA circuits regulate the cancer-inflammation link. Sci Signal, 7:pe8, 2014. 
  1. Fang K, Sideri A, Law IK, Bakirtzi K, Koon HW, Oikonomopoulos A, Hommes DW, Iliopoulos D, Pothoulakis C. Identification of a novel substance P (SP)-neurokinin-1 receptor (NK-1R) microRNA-221-5p inflammatory network in human colonic epithelial cells. Cell Mol Gastroenterol Hepatol, 2015. 
  1. Rodriguez JA, Huerta-Yepez S, Law IK, Baay-Guzman GJ, Tirado-Rodriguez B, Hoffman JM, Iliopoulos D, Hommes DW, Verspaget HW, Chang L, Pothoulakis S, Baritaki S. Diminished expression of CRHR2 in human colon cancer promotes tumor growth and EMT via persistent IL-6/Stat3 signaling. Cell Mol Gastroenterol Hepatol, 1: 610-30, 2015. 
  1. Drakaki A, Hatziapostolou M, Polytarchou C, Vorvis C, Poultsides GA, Souglakos J, Georgoulias V, Iliopoulos D*. Functional microRNA high throughput screening reveals miR-9 as a central regulator of liver oncogenesis by affecting the PPARA-CDH1 pathway. BMC Cancer, 15: 542, 2015. *corresponding author 
  1. Law IK, Bakirtzi K, Polytarchou C, Oikonomopoulos A, Hommes D, Iliopoulos D, Pothoulakis C. Neurotensin-regulated miR-133a is involved in proinflammatory signaling in human colonic epithelial cells and in experimental colitis. Gut, 64: 1095-104, 2015.
  1. Koukos G, Polytarchou C, Kaplan JL, Oikonomopoulos A, Ziring D, Hommes DW, Wahed R, Kokkotou E, Pothoulakis C, Winter HS, Iliopoulos D*. A microRNA signature in pediatric ulcerative colitis: deregulation of the miR-4284/CXCL5 pathway in the intestinal epithelium. Inflamm Bowel Dis, 212: 996-1005, 2015. *corresponding author 
  1. Polytarchou C, Oikonomopoulos A, Joshi S, Touroutoglou A, Koukos G, Hommes DW, Iliopoulos D*. Assessment of circulating microRNAs for the diagnosis and disease activity evaluation in ulcerative colitis patients by using the Nanostring Technology. Inflamm Bowel Dis, 21: 2533-9, 2015. *corresponding author

This is the first study evaluating blood microRNA levels in IBD patients by using the nanostring technology. 

  1. Polytarchou C, Hommes DW, Palumbo T, Hatziapostolou M, Koukos G, van der Meulen-de Jong AE, Oikonomopoulos A, van Deen WK, Vorvis C, Koutsioumpa M, Birli E, Choi J, Chang L, Anton PA, Pothoulakis C, Verspaget HW, Iliopoulos D*. MicroRNA214 is Associated with Progression of Ulcerative Colitis and Inhibition Reduces Development of Colitis and Colitis-associated Cancer in Mice. Gastroenterology, 149: 981-992, 2015. *corresponding author

This work made an impact all over the world as 22 prominent media publications announced the findings of this study. Furthermore, the article was referenced in the cover of the Oct 1st Gastroenterology issue and two editorials were written in the same journal. 

  1. Polytarchou C, Hatziapostolou M, Koutsioumpa M, Kottakis F, Verspaget HW, Hommes DW, Iliopoulos D*. Therapeutically targeting a lincRNA-protein complex in colon cancer through metabolic reprogramming. *corresponding author (under review). 
  1. De Souza H.S, Fiocchi C, Iliopoulos D*. Inflammatory Bowel Disease: an Integrated View of Etiology and Pathogenesis. Nat Rev Gastroenterol Hepatol, 2015 (under review). *corresponding author

ABSTRACTS IN CONFERENCES/MEETINGS

  1. Iliopoulos D, Kouri G, Peristeri B, Rekliti A, Andreou A, Voyiatzis Ν. Double trisomy (48,ΧΧΥ,+21) in a newborn twin (23rd Panhellenic Conference of Hellenic Society for Biological Sciences, Chios, May 2001).
  1. Han SY, Iliopoulos D, Druck T, Grubbs C, Huebner K. Methylation of the murine Fhit  promoter: relations to tumorigenesis (Annual AACR meeting, Washington, USA 2003).
  1. Guler G, Uner A, Guler N, Han SY, Iliopoulos D, Hauck WW, McCue PA, Huebner K. The fragile genes, FHIT and WWOX, are coordinately inactivated in invasive breast cancer: correlations with clinical features (USCAP meeting, Vancouver, Canada, 2004). 
  1. Iliopoulos D, Guler G, Han SY, Johnston D, Weigel R, Herrero J, Huebner K. WWOX, a candidate tumor suppressor gene and possible cancer biomarker and therapeutic target (6th Balkan meeting of medical genetics, Thessaloniki, August 2004).
  1. Semba S, Trapasso F, Fabbri M, McCorkell KA, Volinia S, Druck T, Iliopoulos D, Pekarsky Y, Ishii H, Garrison PN, Barnes LD, Croce CM and Huebner K. Fhit modulation of the Akt-survivin pathway in lung cancer cells: Fhit-tyrosine 114 (Y114) is essential. (Molecular Biology and Cancer Genetics program Biennial Retreat, Atwood Lake Resort, Ohio, USA, 2005).
  1. Fabbri M, Iliopoulos D, Trapasso F, Aqeilan RI, Cimmino A, Zanesi N, Yendamuri S, Han SY, Amadori D, Huebner K amd Croce CM.WWOX gene restoration prevents lung cancer growth in vitro and in vivo (Molecular Biology and Cancer Genetics program Biennial Retreat, Atwood Lake Resort, Ohio, USA, 2005).
  1. Iliopoulos D, Guler G, Guler N, Druck T, Fan M, Han SY, Fabbri M, Semba S, Di Leva G, Weigel R, Nephew K and Huebner K. Wwox is a critical mediator of tamoxifen resistance signal pathways (8th Annual Ohio State University Comprehensive Cancer Center Meeting, NorthPointe, OH, USA).
  1. Iliopoulos D, Guler G, Guler N, Druck T, Fan M, Han SY, Fabbri M, Semba S, Di Leva G, Weigel R, Nephew K and Huebner K. Wwox is a critical mediator of tamoxifen response (AACR meeting, Washington DC, USA, 2006) 
  1. Guler G, Iliopoulos D, Guler N, Himmetoglu C, Hayran M, Huebner K. Wwox and Ap2gamma levels predict tamoxifen response (Annual AACR Meeting, April 2007, Los Angeles, USA).
  1. Iliopoulos D, Satra M, Dalekos GN, Tsezou A E-box methylation in hTERT promoter interferes with c-myc binding and predicts survival in HCC patients (European Human Genetics Conference, Nice, France, June 16-19, 2007).
  1. Satra M, Iliopoulos D, Dalekos GN, Tsezou A.Real-time quantification of human telomerase reverse transcriptase mRNA in liver tissues from patients with hepatocellular cancer and chronic viral hepatitis. (European Human Genetics Conference, Nice, France, June 16-19, 2007).
  1. Iliopoulos D, Tsezou A, Simopoulou T, Stefanou N, Karachalios T, Malizos KN. Differential leptin expression in osteoarthritis of major joints: Effect on Cartilage Metabolism (Annual Meeting of American Orthopaedic Research Society, San Franscisco, 3-5 March 2008).
  1. Drakaki A, Oikonomou P, Tsezou A, Iliopoulos D. MicroRNAs: A novel diagnostic tool in cervical cancer. (American College of Physicians (ACP) Meeting, Waltham, MA, 2008).
  1. Iliopoulos D, Malizos KN, Tsezou A. Leptin as a potential molecular target for osteoarthritis therapeutic intervention (Annual Meeting of American Orthopaedic Research Society, San Franscisco, 3-5 March 2008).
  1. Iliopoulos D, Polytarchou C, Struhl K, Tsichlis PN.MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal programs in cancer cells (100th AACR Annual Meeting, Denver, CO, 20 April, 2009). 
  1. Drakaki A, Oikonomou P, Tsezou A, Iliopoulos D. MicroRNAs: A novel diagnostic tool in cervical cancer. (American College of Physicians (ACP) Meeting, Philadelphia, PA, 2009).
  1. Iliopoulos D. Epigenetic Networks and miRNAs in Cancer Stem Cells (Cancer Genetics & Epigenetics, Gordon Research Conference, Ventura, CA January 26, 2011).
  1. Iliopoulos D. Identifying Novel MicroRNA Networks in Colon Cancer Stem Cells (Molecular Med Tri-Conference, San Franscisco, CA, February 25, 2011)
  1. Iliopoulos D. Inflammatory-EMT Networks in Breast Cancer Stem Cells (102nd AACR Annual Meeting, Orlando, FL, 2 April, 2011).
  1. Hatziapostolou M, Iliopoulos D. Epigenetic-microRNA Networks in Breast Cancer Stem Cells (102nd AACR Annual Meeting, Orlando, FL, 3 April, 2011).
  1. Bakirtzi K, Iliopoulos D, Karagiannidis I, Bugni JM, Hatziapostolou M, Pothoulakis C. Neurotensin (NT) Receptor 1 (Ntr1)-MicroRNA Networks in Human Colon Epithelial Cells. Characterization of Novel Pathways connecting Neurotensin and Tumor Growth (Digestive Diseases Week Meeting, American Gastroenterology Association, Chicago, IL, 8 May, 2011).
  1. Iliopoulos D. The Epigenetic Landscape of Colon Cancer Stem Cells (Digestive Diseases Week Meeting, American Gastroenterology Association, Chicago, IL, 9 May, 2011). 
  1. Polytarchou C, Bugni JM, Dry S, Pothoulakis C, Iliopoulos D. Effects of a neurokinin-1 receptor (NK-1R) antagonist on colon cancer through suppression of colon tumor-initiating cells (ASCO Annual Meeting, Chicago, IL, 3 June, 2011).
  1. Aggelidou E, Drakaki A, Tsiami I, Hatziapostolou M, Tiftikidis G, Polytarchou C, Iliopoulos D, Hadzopoulou-Cladaras M. A TGF-β/miR-24/HNF4a circuit regulates the Epithelial-Mesenchymal Transition in Liver Cells (Annual meeting of the Hellenic Society for Biochemistry and Molecular Biology, Athens, Greece, 9 December, 2011).
  1. Vorvis C, Poultsides G, Norton JA, Iliopoulos D. Identification and Molecular Characterization of Pancreatic Tumor-initiating Cells (103rd Annual AACR Meeting, Chicago, IL, 3 April 2012).
  1. Drakaki A, Hatziapostolou M, Polytarchou C, Poultsides GA, Ogata H, Karin M, Iliopoulos D. MicroRNA-148a Inflammatory Circuit regulates Hepatocellular Oncogenesis (Digestive Diseases Week Annual Meeting, San Diego, CA, 19 May 2012).
  1. Palumbo T, Poultsides GA, Vorvis C, Iliopoulos D. MicroRNA Library Screen reveals MiR-410  as an Anti-Apoptotic Factor in Cholangiocarcinomas (Digestive Diseases Week Annual Meeting, San Diego, CA, 19 May 2012).
  1. Polytarchou C, Palumbo T, Poultsides GA, Vorvis C, Iliopoulos D. MiR-214 as a Therapeutic Target in Ulcerative Colitis(UC)-associated Colon Cancer. (Digestive Diseases Week Annual Meeting, San Diego, CA, 19 May 2012)
  1. Chang L, Iliopoulos D, Polytarchou C, Alberto M, Shih W, Presson AP, Licudine A, Pothoulakis C, Pothoulakis C, Mayer EA.Glucocorticoid Receptor Gene Methylation is a Potential Biomarker for Irritable Bowel Syndrome (Digestive Diseases Week Annual Meeting, San Diego, CA, 19 May 2012).
  1. Koukos G, Polytarchou C, Morley-Fletcher A, Kaplan JL, Pothoulakis C, Winter HS, Iliopoulos D. High Throughput Screening reveals a Novel Epigenetic MicroRNA-Inflammatory Network in Pediatric Ulcerative Colitis (Digestive Diseases Week Annual Meeting, San Diego, CA, 19 May 2012).
  1. Karagiannidis I, Sideri A, Bakirtzi K, Stavrakis D, Polytarchou C, Iliopoulos D, Pothoulakis C, Bradesi S.Chronic Stress increases Systemic and Fat Depot Cytokine Levels and induces Inflammation-associated Signaling Cascades in Adipocytes (Digestive Diseases Week Annual Meeting, San Diego, CA, 19 May 2012).
  1. Law IK, Bakirtzi K, Iliopoulos D, Pothoulakis C. MiR-133a regulates the Endocytosis of a G protein-coupled Receptor in Human Colonocytes (Digestive Diseases Week Annual Meeting, San Diego, CA, 19 May 2012).
  1. Palumbo T, Polytarchou C, Hatziapostolou M, Pothoulakis C, Iliopoulos D. A HNF4A MicroRNA-Inflammatory Circuit is involved in the Pathogenesis of Ulcerative Colitis (Digestive Diseases Week Annual Meeting, San Diego, CA, 19 May 2012).
  1. Polytarchou C, Palumbo T, Bugni JM, Pothoulakis C, Iliopoulos D. Identification of an NK-1R Antagonist as a Novel Therapeutic Approach in Colon Cancer by High Throughput Chemical Screening (Digestive Diseases Week Annual Meeting, San Diego, CA, 19 May 2012).
  1. Hatziapostolou M, Pothoulakis C, Iliopoulos D. A MicroRNA-Epigenetic Circuit regulates Colon Cancer Stem Cells (Digestive Diseases Week Annual Meeting, San Diego, CA, 19 May 2012).
  1. Vorvis C, Poultsides GA, Norton JA, Hatziapostolou M, Iliopoulos D. Identification and Whole Transcriptome Characterization of Pancreatic Cancer Stem Cells (Digestive Diseases Week Annual Meeting, San Diego, CA, 19 May 2012).
  1. Hatziapostolou M, Polytarchou C, Drakaki A, Poultsides GA, Iliopoulos D. MiR-124 Systemic Delivery as a Novel Therapeutic Approach for Hepatocellular Cancer (Digestive Diseases Week Annual Meeting, San Diego, CA, 19 May 2012).
  1. Koukos G, Polytarchou C, Hatziapostolou M, Drakaki M, Pothoulakis C, Iliopoulos D. Adiponectin Inflammatory and Metabolic Networks Regulate the Growth of Colon Tumor-initiating Cells (Digestive Diseases Week Annual Meeting, San Diego, CA, 19 May 2012).
  1. Iliopoulos D. Non Coding RNA feedback loop circuits in oncogenesis (Frontiers in Cancer Research Prevention, AACR, Anaheim, CA, 16 October, 2012).
  1. Iliopoulos D. Identification of Molecular Circuits in Pancreatic Tumor-initiating Cells (PanCan-AACR meeting, Los Angeles, CA, 19 October, 2012).
  1. Iliopoulos D. Identification of Novel Molecular Networks in Pancreatic Cancer by using High Throughput Technologies (2012 Joint APA/IPA Annual Meeting, Miami, FL, 2 November 2012).
  1. Goulidaki N, Polytarchou C, Spandidos D, Sourvinos G, Iliopoulos D. Human Cytomegalovirus dynamically induces a host miRNA response favoring viral lytic infection. (17th World Congress on Advances in Oncology, Crete, Greece, 11 October, 2012).
  1. Goulidaki N, Polytarchou C, Spandidos D, Sourvinos G, Iliopoulos D. Gene targets of cellular miRNAs differentially expressed during human cytomegalovirus infection (17th World Congress on Advances in Oncology, Crete, Greece, 11 October, 2012).
  1. Goulidaki N, Polytarchou C, Spandidos D, Sourvinos G, Iliopoulos D. Human Cytomegalovirus controls the expression of miR-155 and miR-548c through NF-κB activation (17th World Congress on Advances in Oncology, Crete, Greece, 11 October, 2012).
  1. Goulidaki N, Polytarchou C, Spandidos D, Sourvinos G, Iliopoulos D. Identification of host miRNAs that are implicated in the NF-κB and PI3K pathways during human cytomegalovirus lytic infection (17th World Congress on Advances in Oncology, Crete, Greece, 11 October, 2012).
  1. Goulidaki N, Polytarchou C, Spandidos D, Sourvinos G, Iliopoulos D. Human Cytomegalovirus induces alterations in the expression profile of cellular microRNAs regulating the NF-κB pathway to the benefit of viral replication. (63rd Congress of the Hellenic Society of Biochemistry and Molecular Biology, 9 November, 2012).
  1. Goulidaki N, Polytarchou C, Spandidos D, Sourvinos G, Iliopoulos D. NF-κB modulates cellular microRNAs which are affected by human cytomegalovirus and mediate the virally induced NF-κB activation. (63rd Congress of the Hellenic Society of Biochemistry and Molecular Biology, 9 November, 2012)
  1. Goulidaki N, Polytarchou C, Spandidos D, Sourvinos G, Iliopoulos D. Aspirin has antiviral function against human cytomegalovirus (HCMV) through regulation of microRNAs that control NF-κB transcription factor. Hellenic Congress of Clinical Microbiology, Athens, Greece, 1 March, 2013).
  1. Drakaki A, Hatziapostolou M, Polytarchou C, Iliopoulos D. The role of microRNA-9 in hepatocellular oncogenesis (2013 Gastrointestinal Cancers Symposium, American Society for Clinical Oncology, San Franscisco, CA, 24 January, 2013).
  1. Krasoudaki E, Stagakis E, Loupasakis K, Papagianni A, Alexopoulos E, Bertsias G, Iliopoulos D, Boumpas D. MicroRNA analysis of human lupus nephritis. Evidence for modulation of kallikrein 4 by miR-422a. (2013)
  1. Baritaki S, Rodriguez J, Iliopoulos D, Pothoulakis C. Effects of UCN2 and its receptor CRHR2 in colorectal cancer growth and metastasis. (Annual AACR Meeting, Washington DC, April 7, 2013).
  1. Drakaki A, Hatziapostolou M, Polytarchou C, Iliopoulos D. The role of microRNA-9 in hepatocellular oncogenesis. (Annual GI ASCO Meeting, San Francisco CA, January 24, 2013).
  1. Palumbo T, Iliopoulos D, Hatziapostolou M. The oncogenic role of TPPP3 in HCC (AASDL 64th Annual Meeting, Washington, DC, 4 November, 2013).
  1. Fang K, Sideri A, Law IK, Bakirtzi K, Koon HW, Oikonomopoulos A, Hommes DW, Iliopoulos D, Pothoulakis C. Identification of a novel substance P (SP)-Neurokinin-1 Receptor (NK-1R) microRNA-221 inflammatory network in human colonic epithelial cells (DDW meeting, American Gastroenterology Association, Chicago IL, May 3, 2014).
  1. Law IK, Bakirtzi K, Polytarchou C, Koon HW, Hommes DW, Iliopoulos D, Pothoulakis C. Colonic microRNA-133a promotes neurotensin-associated proinflammatory responses in human colonocytes and experimental colitis (DDW meeting, American Gastroenterology Association, Chicago IL, May 3, 2014).
  1. Joshi SM, Polytarchou C, Iliopoulos D, DeYoung J, Mayer EA, Chang L. Global DNA methylation analysis in Irritable Bowel Syndrome (DDW meeting, American Gastroenterology Association, Chicago IL, May 4, 2014).
  1. Koukos G, Polytarchou C, Gras-Miralles B, Kokkotou E, Kaplan JL, Pothoulakis C, Winter H, Iliopoulos D. MicroRNA-4284 regulates CXCL5 expression and is down-regulated in colon tissues of pediatric patients with ulcerative colitis. (DDW meeting, American Gastroenterology Association, Chicago IL, May 5, 2014).
  1. Rodriguez J, Iliopoulos D, Ypez S, Hoffman JM, Baay-Gusman GJ, Tirado-Rodriguez AB, Law IK, Hommes DW, Verspaget HW, Chang L, Pothoulakis C, Baritaki S. Inhibition of corticotropin-releasing hormone receptor 2 (CRHR2) expression in colorectal cancer correlates with tumor growth and EMT in vitro and in vivo, poor patient survival and increased risk for distant metastases (DDW meeting, American Gastroenterology Association, Chicago IL, May 6, 2014).
  1. Bakirtzi K, Law IK, Polytarchou C, Hommes DW, Iliopoulos D, Pothoulakis C. Neurotensin (NT) through the regulation of microRNA (miR)-210 promotes the development of colitis and intestinal angiogenesis (DDW meeting, American Gastroenterology Association, Chicago IL, May 6, 2014).
  1. Koutsioumpa M, Hatziapostolou M, Polytarchou C, Vorvis C, Joshi SM, Iliopoulos D. A novel epigenetic regulator of pancreatic cancer growth. (UCLA CURE Annual Meeting, Los Angeles CA, March 12, 2015).
  1. Fang K, Law IK, Sideri A, Koon HW, Iliopoulos D, Pothoulakis C. Expression of substance P (SP)-regulated miR-31-3p is increased in colitis and modulates RhoA expression in human colonic epithelial cells. (Annual DDW meeting, American Gastroenterology Association, Washington DC, May 16, 2015).
  1. Hatziapostolou M, Koutsioumpa M, Kottakis F, Hommes DW, Verspaget HW, Iliopoulos D, Polytarchou C. Regulation of colon cancer metabolism by a long non-coding RNA. (Annual DDW meeting, American Gastroenterology Association, Washington DC, May 16, 2015).
  1. Polytarchou C, Hommes DW, Palumbo T, Hatziapostolou M, Koukos G, van der Meulen-de Jong AE, Oikonomopoulos A, van Deen WK, Vorvis C, Koutsioumpa M, Birli, Choi JM, Chang L, Anton P, Pothoulakis C, Verspaget HW, Iliopoulos D. Targeting a microRNA for the therapeu of colitis-associated colorectal cancer. (Plenary Session, Annual DDW meeting, American Gastroenterology Association, Washington DC, May 17, 2015).
  1. Koutsioumpa M, Hatziapostolou M, Polytarchou C, Vorvis C, Joshi SM, Iliopoulos D. A novel epigenetic regulator of pancreatic cancer growth. (Annual DDW meeting, American Gastroenterology Association, Washington DC, May 18, 2015).